Serum KL-6 for the evaluation of active pneumonitis in pulmonary sarcoidosis.
نویسندگان
چکیده
KL-6, a mucinous high-molecular weight glycoprotein, expressed on type II pneumonocytes, is elevated in the serum of patients with active interstitial pneumonia. Forty-seven patients with histologically confirmed sarcoidosis were analyzed by chest radiography, CT, 67Ga scintigraphy, BAL fluid (BALF), and serum KL-6. Serum KL-6 level was significantly elevated in radiographic type II (945 +/- 725 U/mL; n = 13; p < 0.01) and type III (1,179 +/- 1,320 U/mL; n = 9; p < 0.01), as compared with type 0 (333 +/- 173 U/mL; n = 10) and type I (430 +/- 225 U/mL; n = 15). Serum KL-6 level was significantly elevated in patients with CT findings of irregular small opacities, ground-glass opacities, and thickened bronchovascular bundle (p < 0.01), as compared to those without these findings. Serum KL-6 level was significantly elevated in patients with positive pulmonary accumulation in 67Ga scintigraphy (1,108 +/- 1,044; n = 20; p < 0.001) as compared to those without accumulation (390 +/- 206; n = 27). Serum KL-6 level was elevated in patients with a higher CD4+/CD8+ ratio (> or =3) in BALF, as compared to those with lower ratios. These results suggest that serum KL-6 is a useful marker of sarcoidosis activity.
منابع مشابه
Usefulness to quantify serum KL-6 levels to follow up uveitic patients with sarcoidosis
Background: KL-6 is a human glycoprotein secreted by type II alveolar cells in lung, and its serum levels increase in pneumonia of various causes. We previously reported that serum KL-6 levels in the uveitis patients with sarcoidosis were significantly higher than that of other uveitis and healthy controls. And combined measurement of serum KL-6 and angiotensin converting enzyme (ACE) was usefu...
متن کاملSeasonal variation of serum KL-6 and SP-D levels in bird-related hypersensitivity pneumonitis.
Bird-related hypersensitivity pneumonitis (HP) is an immunologically mediated lung disease induced by inhalation of bird dropping extracts and antigens in feathers (1). Environmental assessment and removal of the avian antigen are crucial in the management of bird-related HP. Measurement of serum Krebs von den Lungen-6 (KL-6) and surfactant protein D (SP-D) is widely accepted in Japan, as a dia...
متن کاملSerum KL-6 as a novel disease marker in adolescent and adult cystic fibrosis.
BACKGROUND Cystic fibrosis (CF) is a chronic progressive disease leading to obstructive pulmonary impairment, fibrosis and shortened life expectancy. Serum levels of KL-6, high molecular weight human MUC1 mucin, are increased in the majority of patients with various interstitial lung disorders. Whether they are also elevated in CF has not been investigated before. OBJECTIVE To evaluate whethe...
متن کاملSeasonal variation of serum KL-6 concentrations is greater in patients with hypersensitivity pneumonitis
BACKGROUND Serum KL-6 is a useful biomarker for the diagnosis of interstitial lung diseases (ILD). However, KL-6 has not been used to discriminate different types of ILD. Serum KL-6 concentrations can vary depending on antigen exposure levels in patients with hypersensitivity pneumonitis (HP); however, seasonal changes in serum KL-6 concentrations in ILD have not been determined. We hypothesize...
متن کاملCirculating KL-6 levels in patients with drug induced pneumonitis.
BACKGROUND The circulating level of KL-6/MUC1 is a sensitive marker for various interstitial lung diseases. Previous case reports have suggested that KL-6 may also be increased in some patients with drug induced pneumonitis. A study was undertaken to determine whether serum KL-6 could be a marker for particular types of drug induced pneumonitis. METHODS The findings of high resolution compute...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Chest
دوره 109 5 شماره
صفحات -
تاریخ انتشار 1996